|Product Name||HGH Fragment 176-191|
|Synonyms||HGH 176-191, Fragment 176-191, Human Growth Fragment|
|Categories||Peptide;Human Growth Peptide|
|Appearance||White Lyophilized Powder|
|Purity||99% by HPLC|
|Solubility||Soluble in water(Better sterile water)|
|Storage||Lyophilized Fragment 176-191 is stable at room temperature for 90 days, however it should be stored in a freezer below -8℃ for any extended period of time. After reconstituting Fragment 176-191 should be refrigerated at temperatures not to exceed 36 F.|
|Function||1. Enhanced human sexual performance|
2. Hair regrowth
3. Improved cholesterol profile
4. Reduced body fat, weight loss
5. Superior immune function
6. Greater cardiac output
7. Increased muscle mass
The HGH fragment 176-191 stimulates lipolysis and inhibits lipogenesis both en vivo/en vitro. Fragment 176-191 has shown no effect on growth or insulin resistance, unlike the full GH molecule. This is the newest, most powerful GH fragment on the market. Studies have shown sustained fatloss, aimed directly at adipose tissue.
It has been shown that the fat-reducing effects of GH appear to be controlled by a small analog region of the C-terminus end of the GH molecule. This region consists of amino acids 176-191, thus the name. This peptide fragment works by mimicking the way natural hGH regulates fat metabolism but without the adverse effects on blood sugar or growth that is seen with unmodified hGH.
The HGH Fragment is a modified form of amino acids 176-191 at the C-terminal region of the human growth hormone (HGH). Studies have shown that it works by mimicking the way natural HGH regulates fat metabolism but without the adverse effects on insulin sensitivity (blood sugar) or cell proliferation (muscle growth) that is seen with unmodified HGH. Like unmodified GH, the HGH fragment 176-191 stimulates lipolysis (breaking down of fat) and inhibits lipogenesis (the formation of fatty acids and other lipids in the body).
Growth hormone in the body is released in a pulsating fashion. It has been demonstrated that this pattern promotes growth. The pituitary is capable of rather quickly synthesizing very large amounts of growth hormone which it stores in both a finished and unfinished form. Adults rarely experience growth hormone pulses that completely deplete these stores. As we get older we do not lose the ability to create and store large amounts of growth hormone, rather we experience a diminished capacity to instruct their release. The growth hormone pulse is measured in a wave with the trough being the “off” or non-secretion of growth hormone and the crest being the “on” or highest point during growth hormone secretion.
The volume of growth hormone that is released in the body cannot be properly compared to the administration of synthetic growth hormone for the reason that a set of behavioral characteristics associated with natural growth hormone differ from those of synthetic growth hormone. Therefore attempting to find a natural growth hormone to a synthetic growth hormone equivalency is not very productive because in the end what is probably most important is: The quantity and quality of intracellular signaling events and the degree to which growth hormone stimulates autocrine/paracrine (locally produced/locally used) muscle IGF-1 & post-exercise its splice variant MGF.
HGH fragment 176-191 is meant to be 12.5 times stronger than human growth hormone (HGH) for weight loss than standard human growth hormone (HGH).
HGH Fragment 176-191 effect
In addition to directly promote the reduction of fat, the role of HGH Frag 176-191 not too much argument. Individuals are more metabolized and the existing fat burns faster. For this purpose, is it better than conventional HG? This is a difficult question to answer. Some data indicate that it is stronger or more appropriate choice. If fat reduction is the only concern, it is justified to choose this fragment throughout the form. If the blood glucose problem is difficult to control with HGH, it is meaningful to try to give the fragment again. However, when you rely solely on fragments, you will also get rid of HG's almost countless benefits. Recovery, stronger immune system, healing and all relevant anti-aging properties, on this basis, HGH is always a better choice.
Fragment 176-191 as an Active HGH Truncated Peptide
HGH fragment 176-191 is an analog of the growth hormone releasing factor (GRF) which signals the effects of growth hormone. It is a 15-mer peptide residue of the C-terminus of HGH to which tyrosine is added at the N-terminal end. This synthetically produced hormone is very common to weightlifters and bodybuilders because of a number of physical benefits. Studies claimed that it actually acts on the reduction of excessive adipose tissues such as those in the abdominal area, increase in muscle mass, and enhances the lipid content of the body. These segments of the synthetic peptide hgH 176-191 have been investigated for their in vivo effects in laboratory mice musculus. Research results have shown that hgH 176-191 have resulted to a short period increase in blood glucose and a more sustained increase in plasma insulin, together with other fragments such as 172-191, 177-191 and 178-191.
In addition, the researchers have suggested that functionality of the peptide depends not only in the informational sequence but should also have the correct physical configuration (Ng and Borstein 1978). Also, this fragment, being a region of high accessibility to proteases and also rich in proline, have been demonstrated to affect the conformational change in the cytoplasmic domain of the band 3 of erythrocyte membrane protein by serving as the hinge for the pivoting of the two subdomains. This then suggest thatsuch residue is significant in conformational changes be serving as sites for peripheral protein binding in some body cells (Low et al. 1984).
In another study of Ng et al. (2000) on animal subjects, they found out that a 500mcg dosage of the said hormone increased the lipolytic activity in adipose tissues without having negative influence in the blood glucose level. Furthermore, though it behaves like a human growth hormone (hgH), it does not causes hyperglycemia because it does not compete with hgH receptors (Wu et al. 1993). Because of such effects, researchers have suggested that it might be used for the elimination of excess abdominal fat which is a significant aspect of HIV-associated lipodystrophy. The (hgH fragment 176-191) exhibits the ability to burn through stubborn adipose tissue, while increasing energy expenditure, muscle mass, and fat oxidation. All studies have pointed to the fact that the fragment is an effective treatment for obesity and fat loss, and much safer than its Human Growth Hormone counterpart.
Frag 176-191 dosage
HGH Frag is like all of the other Peptides we have covered and come as a delicate lyophilized powder that should be kept out of the light and in a cool dry place. Reconstitution is done with bacteriostatic water or sodium chloride meant for injection. In order to reap the benefits of HGH Frag, users will need to dose around 500mcgs per day. This can be done by dosing 250mcgs in the morning pre-workout, and 250mcgs before lunch or 250mcgs before bed. Users will also want to take note of the timing of injections and their diet at that time. It is optimal to inject HGH Frag 176-191 on an empty stomach or with just protein in the stomach. Like other peptides, HGH Frag has been noted to not work as effectively in the presence of carbohydrates and sugars.
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