Product Name: Tamoxifen citrate
Product Name:Tamoxifen Citrate
Alias: Tamoxifen , Nolvadex ,Tamofen
CAS Registry Number: 54965-24-1
Molecular Formula: C26H29NO.C6H8O7
Molecular weight: 563.64
MP: 140-144 oC
Appearance: white crystalline powder
Usage:the goods to anti-estrogen fertility inducer, the objects in dysfunctional uterine bleeding, polycystic ovary, menstrual disorders and drug-induced amenorrhea and other gynecologic diseases;It is used as a first line defense against breast cancer.
Nolvadex and Clomid are two of the most popular Selective Estrogen Receptor Modulators (SERMs) in the world and part of the supplemental plan for many performance enhancing athletes. More athletes buy Nolvadex for PCT purposes than any other purpose; in-fact, more performance enhancers buy Nolvadex for their PCT use than any other medication available.
In-fact, more performance enhancers buy Nolvadex for their PCT use than any other medication available. As you understand the purpose of the PCT period is to stimulate natural testosterone production after a cycle of anabolic steroids has been discontinued; this is necessary as anabolic steroids suppress natural testosterone production. Further, beyond testosterone stimulation this is the period when we begin normalizing our body but in the case of Tamoxifen Citrate it is testosterone production we are concerned with here.
Gynecomastia(male breast enlargement) is one of the most worrisome side-effects that can occur due to anabolic androgenic steroid use, fortunately you can buy Nolvadex and combat this effect; no, Tamoxifen Citrate will not reduce the amount of estrogen in your body but it will prevent a large portion of it from binding and this provides protectio.
When gyno prone anabolic steroid users run aromatising compounds, such as testosterone or dianabol, they convert to estrogen. This can lead to puffy nipples, bloating, blood pressure, erectile dysfunction and other estrogen related sides. Nolvadex can prevent some estrogen-related side effects from occurring, and it can halt the growth of gynecomastia. However, in my opinion, using an AI is much more effective for overall estrogen control.
In practice, tamoxifen is best used to help boost LH and total testosterone. This will help you recover from a cycle, which makes it a popular choice for post cycle therapy. A clomiphene, tamoxifen combination is one of the best recovery options for most PCT regiments.
Tamoxifen citrate Does not mimic the LH in the body, rather it stimulates the hypophysis to release more gonadotropins. Gonadotropins are protein hormones that are secreted by gonadotrope cells of the pituitary gland and stimulate faster and higher release of follicle stimulating hormone and luteinizing hormone . When this happens, the rise in LH will spike up the total testosterone levels allowing a smooth post cycle therapy. As a result, this will help you minimize any losses in muscle gains until your own body is able to recover.
Interestingly, tamoxifen works just like clomiphene, by stopping estrogen from going into the pituitary, which manipulates it into producing LH. In turn, it then signal the leydig cells to produce testosterone. Many users of nolvadex have run blood work showing LH levels rise from 0 to over 10iu, which is above the normal referenced range for an adult male. As a result of this, your testosterone levels go up.
For the treatment of advanced, recurrent breast cancer and ovarian cancer and other illnesses. Used as an antineoplastic raw materials.
Biological Activity: Estrogen receptor antagonist/partial agonist. Selective and potent inhibitor of mammalian sterol isomerase. Neuroprotective in female rats in vivo . Also high affinity agonist at the membrane estrogen receptor GPR30.
|Product name||Tamoxifen citrate (Nolvadex)|
|Appearance||White crystalline powder|
|Identification||IR, UV conform||Conform|
|Loss on drying||≤ 0.5ml||0.21ml|
|Residue on ignition||Not more than 0.2%||0.06ml|
|Iron||Not more than 0.005%||0.0018%|
|Heavy metals||Not more than 0.001%||0.0006%|
|Related substances||Total: Not more than 1.0%|
Individual: Not more than 0.5%
|E-isomer||Not more than 0.3%||0.19%|
|Organic volatile impurities||Conforms||Conforms|
Tamoxifen citrate Dosage, Indications and Usage:
Tamoxifen Citrate Tablets (TCT) is a competitive estrogen antagonist and a nonsteroidal anti-estrogen drug. It is commonly used clinically to treat all forms of breast cancer, and it is especially suitable for postmenopausal female breast cancer patients who are estrogen receptor and progesterone receptor positive and have relatively low levels of prostrate specific antigens. Tamoxifen citrate has anti-tumor and anti-drug resistance effects, and it can be used for heart protection and treating advanced recurrent breast cancer and ovarian cancer.
Dosage ranges from 10mg - 60mg daily.It is important to start a PCT once you finished a steroid cycle to avoid a dramatic loss of the mass gained. The question on how soon to initiate a PCT depends on the kind of steroids you used. If your cycle is comprised of orals, which have relatively the shortest effect on the body, it is advised to start immediately. Some say PCT can begin as early as the last day of the steroid cycle. If short-acting esters or water-based injectables, PCT is recommended 4-7 days after the last injection. In the case of long-acting esters, it should be around 10-14 days after the last injection.
Tamoxifen citrate User:
Tamoxifen citrate is able to discourage tumor growth as it binds first with the cell receptors even before the estrogen reaches the receptor sites. And we say that tamoxifen citrate is the most trusted and safe medication because it does not suppress the production of estrogen.
Although the drug is already used for years, it has been continuously prescribed by doctors because it is the safest option yet the most effective treatment for hormone receptive positive breast cancers. When we say hormone receptive positive it basically means that the tumor is being fed through estrogen.
Tamoxifen citrate tablets are taken orally and absorbed slowly, taking about 3-6 hours to reach peak blood concentration. After absorption, tamoxifen citrate tablets’ liver metabolite is N- desmethyl tamoxifen, which has similar activity to tamoxifen citrate. The drug’s clearing half-life is 5-7 days and its metabolite N-desmethyl tamoxifen’s half-life is 7-14 days. Animal trials show that tamoxifen citrate and N-desmethyl tamoxifen are widely circulated in the intestines and liver. For a single 20mg dose of tamoxifen citrate, its peak blood values are 40ng/ml (range: 67-183ng/ml) and 336ng/ml (range: 148-654ng/ml). Tamoxifan citrate reaches a stable blood concentration after consistent use for 3-4 weeks, while N-desmethyl tamoxifen requires 3-8 weeks. Tamoxifen citrate and its metabolites are mainly excreted in feces, and a small amount of metabolites is excreted in urine.
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