In a study on it's effects on catabolic states, a once daily oral dose of 25mgs was given to healthy young men subjected to short-term diet-induced nitrogen wasting.
After 7 days of this dose, the subjects showed a sustained increase in serum concentration of IGF-1 and Growth Hormone; in addition, the nitrogen wasting was reversed, showing great potential for treatment of conditions involving muscle wasting.
A study done for the treatment of osteoporosis and bone mineral density showed some increase in bone density, so there is a true impact on bone mineral density. This can help with injury recovery during your cycle.
Other possible benefits of Nutrobal are associated with improved sleep, improved complexion, increase in energy levels, increase nitrogen retention, increase strength and an improved sense of well being. In addition, some studies also suggest that an increased immune system response was caused by Nutrobal (Mk-677), meaning it boosts the immune system to a degree.
How it Works:
Growth hormone pulse intensity can be increased through 4 possible mechanisms*:
Increasing GHRH (growth hormone releasing hormone) release.
Amplifying GHRH signaling in somatotrophs of the anterior pituitary gland.
Reducing somatostatin release (somatostatin turns off GH release).
Inhibiting of somatostatin receptor signaling.
Note:Nutrobal (Mk-677) was found to work through all four of these mechanisms. After ingestion, Growth Hormone (GH) was shown to increase dose dependently, at doses starting at 5 milligrams (mgs) a day.
The recommended dosage of MK677 is 5-25mg daily, taken in a 10-week cycle. It may be necessary to adjust the dose to continue to get optimal results and in some cases up to 50mg has been taken, but that's not generally necessary or advisable.
The liquid form should be squirted straight into the mouth and chased down with water or juice. It shouldn't be mixed before drinking.
Half life info:
The half life of MK677 is 24 hours so you'll only need to take it once a day. The most common route of administration is the liquid form, taken on an empty stomach first thing in the morning, every day.
Those who take MK677 suggest that it's almost impossible to gain fat while taking the drug, so strong is its fat loss effect.
You can stack it with other SARMs such as cardarine or andarine for a fat-burning cycle which is incredibly potent, or take it alone and you'll still achieve a shredded appearance. The other benefit is that MK677 packs on lean tissue so even if you're on a calorie restricted diet, you will still hang on to your muscle.
On an MK677 bulking cycle you can expect to gain several pounds rapidly and continue to gain for the rest of the cycle. It's a compound which delivers fast results without compromising on the quality.
A bulking cycle often means accumulating an increase in body fat temporarily, but that isn't the case with MK677. You won't be piling on unwanted fat that you'll need to later shed making it perfect for bulking either on its own or in a stack.